Tag Archives: SAMD9L

Haploinsufficiency of SAMD9L, an Endosome Fusion Facilitator, Causes Myeloid Malignancies in Mice Mimicking Human Diseases with Monosomy 7 via Cancer Cell (Science Direct)

Highlights •SAMD9L-deficient mice develop myelodysplastic syndrome in their advanced age •SAMD9L enhances reconstitution ability of hematopoietic stem cells •SAMD9L degrades cytokine receptors through the homotypic fusion of endosomes •Haploinsufficiency of SAMD9L mimics human myeloid malignancies with monosomy 7 Summary Monosomy 7 and … Continue reading

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