The Game Changer Chicago Design Lab (GCC) is an initiative in which youth collaborate with faculty and university students to create digital stories and games in order to explore health and social issues. GCC uses gameplay and game design to create youth-directed, problem-based and collaborative learning opportunities and outcomes. GCC programs and workshops help youth hone skills in media literacy, critical inquiry, storytelling techniques and game design. We use rapid prototyping, play testing, evaluation and redesign to create games and projects informed by theories of change. GCC was co-founded by Drs. Melissa Gilliam and Patrick Jagoda, and is part of the Center for Interdisciplinary Inquiry and Innovation in Sexual and Reproductive Health (Ci3) at The University of Chicago. Note: All characters appearing in our work are fictitious. Any resemblance to real persons, living or dead, is purely coincidental.